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     當前位置:新聞 -> 新技術 -> 脫細胞異體真皮可有效修復大面積口腔上皮缺損
    脫細胞異體真皮可有效修復大面積口腔上皮缺損
    時間:2021-03-18 09:31:13  作者:Annie  來源:再生醫學網綜合報道
    作者認為,切除大面積舌和頰白斑后,用脫細胞異體真皮修復大面積口腔上皮缺損,這是預防口腔白斑惡性轉化的安全可靠的方法;臨床醫生必須注重一級預防,以降低由可預防原因而引起的癌前疾病的發病率和發生率。


      中山大學孫逸仙紀念醫院陳偉良教授等于2021年2月在SCI期刊《J Cosmet Dermatol》(2021 Feb 3.doi:10.1111/jocd.13973)發表了最新研究文章《Use of allograft dermal matrix for repairing large oral epithelial defects:Outcomes of patients with lingual and buccal leukoplakia(脫細胞異體真皮在口腔上皮大面積缺損修復中的應用)》。作者認為,切除大面積舌和頰白斑后,用脫細胞異體真皮修復大面積口腔上皮缺損,這是預防口腔白斑惡性轉化的安全可靠的方法;臨床醫生必須注重一級預防,以降低由可預防原因而引起的癌前疾病的發病率和發生率。再生醫學網摘選部分內容進行分享,和大家一起交流。
      作者觀點
      * Large epithelial defect reconstruction using an HADM following resection of wide lingual and buccal OLs was safe and reliable for preventing MT of OL.The recurrence of OL may be related to patient habits such as tobacco smoking or/and drinking alcohol.
      * The management of OLs is complex.The transition from normal mucosa to premalignant or dysplastic mucosa,and finally to MT,involves a complex interplay among environmental factors,including exposure to carcinogens(such as betel liquid,tobacco,and alcohol)and HPV,genetic factors,and the host immune system.
      * It is therefore imperative that clinicians focus on primary prevention to reduce the prevalence and incidence of premalignant disease resulting from preventable causes.
      * It is believed that reconstruction of large epithelial defects with HADM,following resection of wide lingual and buccal OLs,is safe and reliable for preventing MT of OL.
      * The recurrence of OLs following resection may be related to the patient's habits,such as tobacco smoking or/and drinking alcohol.
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